Track47: Genetic influences on drug response

18th International Conference & Exhibition on Pharmacology, Drug Discovery & Clinical Trials
18th International Conference and Exhibition on Pharmacology, Drug Discovery, Pharmacotherapy
Genetic Influences on Drug Response—often referred to as pharmacogenetics or pharmacogenomics—describe how an individual’s genetic makeup affects their response to medications. Variations in genes can influence how drugs are absorbed, distributed, metabolized, and eliminated, as well as how they interact with their biological targets.

Genetic differences may determine whether a drug is highly effective, partially effective, or ineffective, and can also increase the risk of adverse drug reactions or toxicity. For example, variations in drug-metabolizing enzymes (such as CYP450 enzymes), drug transporters, or receptor proteins can lead to faster or slower drug metabolism, requiring dose adjustments or alternative therapies.

Understanding genetic influences on drug response supports the development of personalized medicine, enabling healthcare professionals to select the most appropriate drug and dosage for each patient. This approach improves treatment efficacy, enhances patient safety, reduces trial-and-error prescribing, and contributes to more cost-effective healthcare outcomes.